Clinical Risk Calculator

Fibrosis Screening Index (FSI)

A simple first-line tool based on routinely available clinical variables to support liver fibrosis risk assessment in populations targeted for fibrosis case-finding.

Target population

The FSI is intended for adults with one or more of the following risk factors:

Type 2 diabetes mellitus
Obesity with additional cardiometabolic risk factors
Elevated liver enzymes
Imaging evidence of hepatic steatosis

Calculate FSI

Age (years)

BMI (kg/m²)

AST (U/L)

GGT (U/L)

Platelet count (×10⁹/L)

Diabetes status

FSI formula

FSI = −15.269 + 0.032 × Age + 0.544 × Diabetes status + 0.197 × BMI + 1.039 × ln(AST) + 0.585 × ln(GGT) + 136.396 × (1 / Platelet count)

Age is expressed in years, BMI in kg/m², AST and GGT in U/L, and platelet count in ×10⁹/L. Diabetes status is coded as 0 (no) or 1 (yes). ln denotes the natural logarithm.

Clinical interpretation

Clinicians can use the FSI to assess fibrosis risk and identify individuals who may benefit from further evaluation or specialist referral. Individuals classified as low risk may continue routine clinical management and follow-up. Individuals classified as intermediate or high risk may benefit from further assessment with VCTE and specialist evaluation when clinically appropriate.

Disclaimer: The FSI is intended to support clinical risk assessment and does not replace clinical judgment, VCTE, liver biopsy, or other diagnostic evaluation. Clinical decisions should consider the patient's overall clinical context and applicable local guidance.

Contact

For questions or feedback regarding the FSI calculator:
Email: 22022628@shutcm.edu.cn